Endocrine Abstracts

Introduction: Hypercortisolism in Cushing’s syndrome (CS) determines increased mortality and morbidity. Hypercortisolism is also present in chronic depressive disorders and stress, where telomere length (TL) is shorter than in controls. We hypothesized that telomere shortening may occur and contribute to premature morbidity in CS.Aim: Investigate TL in CS compared to matched controls, and longitudinally in a subset of CS patients evaluated both with...

AimObesity was shown to be related to global cognitive decline, being especially altered the executive function and the information processing speed. Additionally, sarcopenic obesity (SO) was associated independently with a deterioration in global cognition, executive function, information processing speed, global memory and cerebral atrophy in patients > 65 years. However, at present there is no data regarding the role of sarcopenia in the cognitive...

Introduction: Cushing’s syndrome (CS) is associated with increased mortality and morbidities. Hypercortisolism is also present in chronic mood disorders (CMD) and stress, where telomere length (TL) has been found to be shorter than in matched controls. Since hypercortisolism is present in CS and CMD, we hypothesized that telomere shortening could also be present in CS. The aim of this study was to investigate TL in CS patients compared to matched controls.<p class="ab...